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Cake day: March 31st, 2025

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  • DCM is also about the only good solvent left that is also resistant to lewis acids. I think that some people were pushing for benzotrifluoride as a replacement, but it just straight up doesn’t work as well where i tried it

    Tbf before “do it in DCM” was “do it in CCL4” or “do it in benzene”, DCM just works without nuking operator’s liver

    Lots of these new green solvents are also annoyingly polar so perhaps they can be used as replacements of other polar solvents but not anything else. I’m not using cyrene, fuck that

    TFA is used because it works and is shelf-stable. Replacements like HCl in ether or ethyl acetate are bitch to make and when these can be bought, they have to be refrigerated all the way. Straight up not worth the effort on small scale