I thought this was being tested a couple of years ago?
Kinda hard to make male contraceptives. Women are naturally infertile for most of the time not spent actively ovulating. They are permanently infertile during pregnancy, real or synthetic. But men? We’re always churning out swimmers. When that process stops, something has gone very wrong.
So, artificially induce a naturally occurring phenomenon vs artificially terminate a constant mechanism.
Well not with that attitude!
It is more difficult, but still worth working towards it.
I have a different solution, its called being a transbian :3
How so? Unless you remove testicles, or your partner is also a trans person, you’re still 100% able to have offspring together
I was being more silly than serious :3
Hehe alright!
Easier to target one egg cell than millions of sperm germ cells.
Sure. But the demand is here on both sides, not just one.
Male contraceptives allow men to have reproductive agency beyond condoms and vasectomy, and they can be used in couples where women prefer not to use non-barrier contraception for health reasons or personal reservations.
My situation right here. Condoms suck, vasectomy is too much, and birth control isn’t on the table. Please give me a pill already.
…in mice, after massive, cancer-causing doses, probably.
I’m tired of hearing about this shit. Put it to market or stop talking about it.
Yeah just push it out to public. Just like they did with women’s contraceptives.
Last I heard there were some of these contraceptives moving into clinical trials, the ones with gel in the vas deferens,
Anyway it is irrelevant for regular people, because it isn’t available and probably won’t be within 5 to 10 years if lucky. Maybe it would be relevant if it had a chance of being available in 1 to 2 years , even then who knows how expensive it would be or how long it would take to be accessible, as in a lot of doctors doing it.
Vasagel, based on an Indian product called RISUG
Noone funds it because it’s too cheap? No real profit potential?
Essentially – it’s a gel that’s injected into the vas def which doesn’t actually block the flow totally (which sometimes causes side effects like granuloma in vasectomy), but rather it disrupts sperm cell membranes, but allowing the remains to pass through.
It is reversed simply by flushing it out with saline.
Last time I donated to the project it was at the live rabbit trials stage with Parsemuns Foundation?
(OH WAIT IT HAS BEEN USED IN HUMANS IN THE USA (see wired link below)
RISUG was used in humans for like 20 years with good results I believe.
Really don’t understand why this one hasn’t gained traction.
https://www.planaformen.com/vasalgel
https://en.wikipedia.org/wiki/Reversible_inhibition_of_sperm_under_guidance
https://www.wired.com/story/male-contraceptive-contraline-vasalgel-hydrogel/
(Ohh right the rabbit study was for reversibility)
This kind of news is an annual event at this point.
this is way less reversible than they claim
Didn’t they figure that out with Vasalgel?
If it did, you’d think it would be promoted, like at all. I never hear about it.
I was about a decade or two ago, but then the news stopped. No idea what’s been going on with it since.
I just use my personality. Seems simpler.
The new stuff is reversible
In my case it is even easier. I’m short, so I am invisible to women.
Dude I am an ogre who looks borderline homeless and when the Goodwill cashier saw my points balance her eyes lit up and said “you’re rich” and she was chatty Cathy for the whole transaction.
Don’t be short, be rich!
Not if you’re also loooong.
I thought it was your looks?
Recently, the smell.
The Complete Package.
Ooo that’s rare.
Nah, they’d gladly prevent trans women , who they view as men, from getting gender affirming care. They would try to prevent this on the same grounds of “it’s not natural to mess with people’s hormones”
To achieve this, scientists used JQ1, a small molecule inhibitor originally developed to study cancer and inflammatory diseases. While JQ1 is not suitable as a treatment due to neurological side effects, it is known to interfere with a stage of meiosis called prophase 1.
While JQ1 is not suitable as a treatment due to neurological side effects
That doesn’t sound very safe.
Should have just used bleach if they don’t care about it actually being a viable treatment. Or, for that matter, we’ve already invented spermicidal foam…
Bruh the cancer lab (prostate cancer out of all things) I worked in as an undergrad was studying JQ1. Couldn’t believe I’d ever hear this drug name again. Really hope this can go somewhere, reversible contraceptive sounds exciting
You still in the field or did you go another way?
I’m back in cancer research for my current job again. But not in prostate… and more importantly, I’m on the computational side of things instead of experimental now
Also as to the topic… there were a few people in my undergrad lab who were actively studying JQ1 (back in 2017-18), but I’ve never heard much about the drug after I left. Thanks to you I finally found out why I never heard about it again (neurological side effects) so
its just a feeling I can relate to. I moved from blood diagnostics to it looooooonnnng ago.
So the substance isn’t a possible treatment for cancer because of neurological side effects… and their next step is “let’s sell it to guys who aren’t able to use condoms”?
If I read it correctly it’s double win for guys who have cancer and don’t want to reproduce.
I think the idea is that this particular drug isn’t suitable as birth control, but having identified that this mechanism/biological pathway can work for birth control, they can look for a less toxic compound to achieve the same effect.
sounds that way to me. I think the thing like always is the title. its something they noticed and now a track to find something that does a similar type of mechanism without the bad side effects.
Yes, I know some of these words and concur.
again.
Why does the egg look like that??
They’ve had something similar available for years. It’s a small plastic square about the size of a lego brick. You put it in your shoe and it makes you limp
