For me, it would be GLaDOS.
Portal 2 spoiler
She deleted the one remaining human part of herself because it was just too much to deal with. She releases you at the end of Portal 2 as a path of least resistance measure because “killing you is hard.”
What about you, what is your favorite media villain?
probably Junko Enoshima because she’s so unmatchedly fucking bonkers batshit kookoo bananas unhinged
insanebut keeps it together just well enough to cause an apocalypse by shitposting really hard